| Gene |
HDAC7
|
| Protein Name |
HDAC7_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) |
| Protein Family |
Histone deacetylase family |
| NCBI Gene ID |
51564
|
| UniProt ID |
Q8WUI4
|
| Enzyme Class |
3.5.1.98 |
| Molecular Weight |
102927 |
| Protein Length |
952 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. |
| Localization |
Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation. |
| Function (UniProt annotation) |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). |
| Gene Ontology |
GO:0000118; GO:0000122; GO:0001570; GO:0003682; GO:0003714; GO:0005080; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0007043; GO:0019789; GO:0019901; GO:0032041; GO:0032703; GO:0033613; GO:0045668; GO:0046872; GO:0070491; GO:0071889; GO:0090050; GO:1901223 |
