| Gene |
NOX5
|
| Protein Name |
NOX5_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
NADPH oxidase 5 (EC 1.6.3.-) |
| Protein Family |
N/A |
| NCBI Gene ID |
79400
|
| UniProt ID |
Q96PH1
|
| Enzyme Class |
1.6.3.- |
| Molecular Weight |
86439 |
| Protein Length |
765 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Membrane; Isoform v2: Endoplasmic reticulum.; Isoform v5: Endoplasmic reticulum. |
| Function (UniProt annotation) |
Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin. |
| Gene Ontology |
GO:0001525; GO:0001935; GO:0005509; GO:0005783; GO:0005789; GO:0006915; GO:0008283; GO:0010155; GO:0015252; GO:0016021; GO:0016175; GO:0020037; GO:0034599; GO:0042554; GO:0043012; GO:0050660; GO:0050661; GO:0050663; GO:0055114; GO:0061640; GO:2000379 |
