| Gene |
RBM14
|
| Protein Name |
RBM14_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) |
| Protein Family |
N/A |
| NCBI Gene ID |
1.01E+13
|
| UniProt ID |
Q96PK6
|
| Enzyme Class |
- |
| Molecular Weight |
69492 |
| Protein Length |
669 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). |
| Gene Ontology |
GO:0002218; GO:0003712; GO:0003723; GO:0005634; GO:0005654; GO:0005667; GO:0005730; GO:0005737; GO:0006260; GO:0006281; GO:0006310; GO:0009725; GO:0016575; GO:0016592; GO:0016607; GO:0030374; GO:0030520; GO:0030674; GO:0042921; GO:0045087; GO:0045944; GO:0046600; GO:0060395; GO:0098534; GO:1990904 |
