| Gene |
DLC1
|
| Protein Name |
RHG07_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) |
| Protein Family |
N/A |
| NCBI Gene ID |
10395
|
| UniProt ID |
Q96QB1
|
| Enzyme Class |
- |
| Molecular Weight |
170591 |
| Protein Length |
1528 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm. Cell junction, focal adhesion. Membrane; Peripheral membrane protein. Note=Colocalizes with EF1A1 at actin-rich regions in the cell periphery. |
| Function (UniProt annotation) |
Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. |
| Gene Ontology |
GO:0001843; GO:0003007; GO:0005096; GO:0005634; GO:0005737; GO:0005829; GO:0005901; GO:0005925; GO:0006915; GO:0006919; GO:0007165; GO:0008285; GO:0008289; GO:0008360; GO:0021575; GO:0030036; GO:0030336; GO:0030864; GO:0030900; GO:0032587; GO:0032956; GO:0035024; GO:0035307; GO:0042169; GO:0048041; GO:0051056; GO:0051497; GO:0051895; GO:1900119 |
