CaMKinet | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Parameter	Value
Gene	PASK
Protein Name	PASK_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1)
Protein Family	Protein kinase superfamily
NCBI Gene ID	23178
UniProt ID	Q96RG2
Enzyme Class	2.7.11.1
Molecular Weight	142929
Protein Length	1323
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	ATP + a protein = ADP + a phosphoprotein.
Localization	Cytoplasm Note=Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails.
Function (UniProt annotation)	Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.
Gene Ontology	GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006468; GO:0035091; GO:0035556; GO:0043576; GO:0045719; GO:0045727; GO:0046777; GO:0070092; GO:0097009

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PASK (Q96RG2)	Homo sapiens	T1161	ERGKLFYTFCGTIEY	0.673	0.0178	TP	certain	experimental	31 \| 94 \| 9 \|	11459942	-	-
PASK (Q96RG2)	Homo sapiens	T1165	LFYTFCGTIEYCAPE	0.644	0.0198	TP	certain	experimental	31 \| 94 \| 9 \|	11459942	-	-
PASK (Q96RG2)	Homo sapiens	S1149	IKLIDFGSAAYLERG	0.353	0.0148	-	-	-	-	-	-	-
PASK (Q96RG2)	Homo sapiens	S1273	FRVNKPESGVLSAAS	0.686	0.384	-	-	-	-	-	-	-
PASK (Q96RG2)	Homo sapiens	S1277	KPESGVLSAASLEMG	0.506	0.5098	-	-	-	-	-	-	-
PASK (Q96RG2)	Homo sapiens	S1280	SGVLSAASLEMGNRS	0.606	0.5176	-	-	-	-	-	-	-
PASK (Q96RG2)	Homo sapiens	S1287	SLEMGNRSLSDVAQA	0.513	0.4582	-	-	-	-	-	-	-
PASK (Q96RG2)	Homo sapiens	S1289	EMGNRSLSDVAQAQE	0.746	0.4017	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found