| Gene |
UIMC1
|
| Protein Name |
UIMC1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) |
| Protein Family |
RAP80 family |
| NCBI Gene ID |
51720
|
| UniProt ID |
Q96RL1
|
| Enzyme Class |
- |
| Molecular Weight |
79727 |
| Protein Length |
719 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). |
| Function (UniProt annotation) |
Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.37). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. |
| Gene Ontology |
GO:0005634; GO:0005654; GO:0006302; GO:0006303; GO:0010212; GO:0016579; GO:0016604; GO:0042393; GO:0045739; GO:0045892; GO:0070530; GO:0070531; GO:0070537; GO:0072425 |
