| Gene |
SIN3A
|
| Protein Name |
SIN3A_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) |
| Protein Family |
N/A |
| NCBI Gene ID |
25942
|
| UniProt ID |
Q96ST3
|
| Enzyme Class |
- |
| Molecular Weight |
145175 |
| Protein Length |
1273 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus Note=Recruited to the nucleolus by SAP30L. |
| Function (UniProt annotation) |
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). |
| Gene Ontology |
GO:0000122; GO:0000776; GO:0000785; GO:0000976; GO:0001102; GO:0001103; GO:0001701; GO:0002218; GO:0002230; GO:0002244; GO:0003682; GO:0003700; GO:0003714; GO:0003723; GO:0005634; GO:0005654; GO:0005667; GO:0005730; GO:0006260; GO:0006476; GO:0007568; GO:0010817; GO:0010971; GO:0016575; GO:0016580; GO:0017053; GO:0019216; GO:0031937; GO:0033558; GO:0034613; GO:0042754; GO:0043066; GO:0043619; GO:0044877; GO:0045652; GO:0045892; GO:0045944; GO:0048511; GO:0051595; GO:0071333; GO:1900181; GO:1901675; GO:1903351; GO:2000678 |
