| Gene |
SPEN
|
| Protein Name |
MINT_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) |
| Protein Family |
RRM Spen family |
| NCBI Gene ID |
23013
|
| UniProt ID |
Q96T58
|
| Enzyme Class |
- |
| Molecular Weight |
402248 |
| Protein Length |
3664 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus Note=Associates with chromatin. |
| Function (UniProt annotation) |
May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. |
| Gene Ontology |
GO:0000122; GO:0001085; GO:0003677; GO:0003714; GO:0003723; GO:0005634; GO:0005654; GO:0007219; GO:0016032; GO:0017053; GO:0045892; GO:0050769; GO:0070062 |
