| Gene |
WNK1
|
| Protein Name |
WNK1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
65125
|
| UniProt ID |
Q9H4A3
|
| Enzyme Class |
2.7.11.1 |
| Molecular Weight |
250794 |
| Protein Length |
2382 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity). |
| Gene Ontology |
GO:0000287; GO:0002028; GO:0003084; GO:0004672; GO:0004674; GO:0005524; GO:0005737; GO:0005829; GO:0006468; GO:0006811; GO:0010766; GO:0010820; GO:0010923; GO:0016020; GO:0018105; GO:0018107; GO:0019869; GO:0019870; GO:0019901; GO:0019902; GO:0023016; GO:0030291; GO:0030295; GO:0032414; GO:0033633; GO:0034115; GO:0034260; GO:0035556; GO:0038116; GO:0046777; GO:0048666; GO:0050794; GO:0050801; GO:0050852; GO:0071277; GO:0090188; GO:0090263; GO:0097022; GO:1903038; GO:1903288; GO:1990869; GO:2000651 |
