| Gene |
SENP2
|
| Protein Name |
SENP2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Sentrin-specific protease 2 (EC 3.4.22.-) (Axam2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Sentrin/SUMO-specific protease SENP2) |
| Protein Family |
Peptidase C48 family |
| NCBI Gene ID |
59343
|
| UniProt ID |
Q9HC62
|
| Enzyme Class |
3.4.22.- |
| Molecular Weight |
67855 |
| Protein Length |
589 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus, nuclear pore complex |
| Function (UniProt annotation) |
Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620). |
| Gene Ontology |
GO:0001934; GO:0005634; GO:0005643; GO:0005654; GO:0005829; GO:0007507; GO:0009950; GO:0015031; GO:0016055; GO:0016605; GO:0016925; GO:0016926; GO:0019904; GO:0030111; GO:0031397; GO:0031398; GO:0031648; GO:0031965; GO:0032091; GO:0032875; GO:0035562; GO:0045444; GO:0045944; GO:0051028; GO:0060707; GO:0060711; GO:0060712; GO:0070139; GO:0070140; GO:2000045 |
