| Gene |
PNPLA8
|
| Protein Name |
PLPL8_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Calcium-independent phospholipase A2-gamma (EC 3.1.1.5) (Intracellular membrane-associated calcium-independent phospholipase A2 gamma) (iPLA2-gamma) (PNPLA-gamma) (Patatin-like phospholipase domain-containing protein 8) (iPLA2-2) |
| Protein Family |
N/A |
| NCBI Gene ID |
50640
|
| UniProt ID |
Q9NP80
|
| Enzyme Class |
3.1.1.5 |
| Molecular Weight |
88477 |
| Protein Length |
782 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate. |
| Localization |
Endoplasmic reticulum membrane |
| Function (UniProt annotation) |
Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids. |
| Gene Ontology |
GO:0000139; GO:0001516; GO:0004622; GO:0004623; GO:0005524; GO:0005622; GO:0005777; GO:0005778; GO:0005789; GO:0006631; GO:0008219; GO:0016020; GO:0016021; GO:0019369; GO:0034638; GO:0036151; GO:0036152; GO:0043651; GO:0046338; GO:0047499; GO:0048471; GO:0050482 |
