CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	HOMER3
Protein Name	HOME3_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Homer protein homolog 3 (Homer-3)
Protein Family	Homer family
NCBI Gene ID	9454
UniProt ID	Q9NSC5
Enzyme Class	-
Molecular Weight	39836
Protein Length	361
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm
Function (UniProt annotation)	Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation through negative regulation of IL2 expression by inhibiting calcineurin-NFAT pathway activation through interaction with NFATC2 leading to reduction of interaction between NFATC2 and PPP3CA (PubMed:18218901).
Gene Ontology	GO:0005737; GO:0005829; GO:0005886; GO:0006605; GO:0007216; GO:0014069; GO:0030054; GO:0030425; GO:0032703; GO:0035256; GO:0042802; GO:0043005; GO:0045211; GO:0070885; GO:2001256

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK2A (Q9UQM7)	Homo sapiens	S120	ARLAREKSQDGGELT	0.386	0.6948	-	-	-	-	-	-	-
CAMK2A (Q9UQM7)	Homo sapiens	S159	EKLFRSQSADAPGPT	0.688	0.8741	-	-	-	-	-	-	-
CAMK2A (Q9UQM7)	Homo sapiens	S176	ERLKKMLSEGSVGEV	0.328	0.5419	-	-	-	-	-	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found