CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	AATF
Protein Name	AATF_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1)
Protein Family	AATF family
NCBI Gene ID	26574
UniProt ID	Q9NY61
Enzyme Class	-
Molecular Weight	63133
Protein Length	560
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Nucleus, nucleolus
Function (UniProt annotation)	May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
Gene Ontology	GO:0003723; GO:0005634; GO:0005730; GO:0005737; GO:0005794; GO:0006974; GO:0007155; GO:0007346; GO:0019901; GO:0032929; GO:0040016; GO:0042254; GO:0042985; GO:0043066; GO:0043522; GO:0045944; GO:0048156; GO:2000378

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
MAPKAPK2 (P49137)	Homo sapiens	T366	FTVYRNRTLQKWHDK	0.687	0.2328	TP	certain	experimental	45 \| 72 \| 9 \|	22909821	-	-
CHEK2 (O96017)	Homo sapiens	S143	SKKSRSHSAKTPGFS	0.131	0.6991	-	-	-	-	-	-	In vitro
CHEK2 (O96017)	Homo sapiens	S477	ELIERKTSSLDPNDQ	0.237	0.4256	-	-	-	-	-	-	In vitro
CHEK2 (O96017)	Homo sapiens	S510	KKVDRKASKGRKLRF	0.618	0.3631	-	-	-	-	-	-	In vitro

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found