CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	RRN3
Protein Name	RRN3_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	RNA polymerase I-specific transcription initiation factor RRN3 (Transcription initiation factor IA) (TIF-IA)
Protein Family	RRN3 family
NCBI Gene ID	54700
UniProt ID	Q9NYV6
Enzyme Class	-
Molecular Weight	74107
Protein Length	651
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Nucleus, nucleolus
Function (UniProt annotation)	Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity).
Gene Ontology	GO:0001042; GO:0001164; GO:0001181; GO:0001701; GO:0005634; GO:0005654; GO:0005730; GO:0006361; GO:0007000; GO:0007028; GO:0008283; GO:0010976; GO:0042254; GO:0045893; GO:0048872; GO:1902254; GO:2000142

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
RPS6KA3 (P51812)	Homo sapiens	S649	PVLYMQPSPL_____	0.5	0.4901	TP	certain	experimental	3 \| 23 \| 73 \| 273 \| 9 \| 72 \|	12620228	-	In vivo
PRKAA1 (Q13131)	Homo sapiens	S635	DTHFRSPSSSVGSPP	0.237	0.4087	-	-	-	-	-	-	In vitro and in vivo
RPS6KA2 (Q15349)	Homo sapiens	S649	PVLYMQPSPL_____	0.5	0.4901	-	-	-	-	12620228	Non high throughput (12620228)	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found