| Gene |
Syngap1
|
| Protein Name |
SYGP1_RAT |
| Organism |
Rattus norvegicus (Rat) |
| Alternative name(s) |
Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1) (p135 SynGAP) |
| Protein Family |
N/A |
| NCBI Gene ID |
N/A
|
| UniProt ID |
Q9QUH6
|
| Enzyme Class |
- |
| Molecular Weight |
144722 |
| Protein Length |
1308 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Membrane; Peripheral membrane protein. Cell junction, synapse. Note=Mostly in excitatory glutamatergic synapses. |
| Function (UniProt annotation) |
Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits. |
| Gene Ontology |
GO:0005096; GO:0007165; GO:0014069; GO:0016020; GO:0017124; GO:0019901; GO:0030054; GO:0045202; GO:0046580; GO:0048167; GO:0098978; GO:0099092 |
