| Gene |
PI4KB
|
| Protein Name |
PI4KB_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) (NPIK) (PI4K92) |
| Protein Family |
PI3/PI4-kinase family |
| NCBI Gene ID |
5298
|
| UniProt ID |
Q9UBF8
|
| Enzyme Class |
2.7.1.67 |
| Molecular Weight |
91379 |
| Protein Length |
816 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate. |
| Localization |
Endomembrane system. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus. Golgi apparatus membrane |
| Function (UniProt annotation) |
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity). |
| Gene Ontology |
GO:0000139; GO:0004430; GO:0005524; GO:0005737; GO:0005741; GO:0005768; GO:0005829; GO:0006661; GO:0006898; GO:0007165; GO:0016020; GO:0030867; GO:0046854; GO:0048015; GO:0048471; GO:0071889 |
