| Gene |
ERRFI1
|
| Protein Name |
ERRFI_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) |
| Protein Family |
MIG6 family |
| NCBI Gene ID |
54206
|
| UniProt ID |
Q9UJM3
|
| Enzyme Class |
- |
| Molecular Weight |
50560 |
| Protein Length |
462 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). |
| Gene Ontology |
GO:0005096; GO:0005634; GO:0005737; GO:0005829; GO:0007175; GO:0017124; GO:0019901; GO:0031234; GO:0031267; GO:0031953; GO:0032691; GO:0032869; GO:0032966; GO:0036120; GO:0042059; GO:0042536; GO:0043589; GO:0045616; GO:0048286; GO:0060426; GO:0060428; GO:0061469; GO:0070373; GO:0071364; GO:0071474; GO:0071549; GO:1903243 |
