CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	HDAC9
Protein Name	HDAC9_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR)
Protein Family	Histone deacetylase family
NCBI Gene ID	9734
UniProt ID	Q9UKV0
Enzyme Class	3.5.1.98
Molecular Weight	111297
Protein Length	1011
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Localization	Nucleus
Function (UniProt annotation)	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription.; Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.
Gene Ontology	GO:0000118; GO:0000122; GO:0001975; GO:0003714; GO:0004407; GO:0005080; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0006954; GO:0007507; GO:0008134; GO:0016575; GO:0030182; GO:0030183; GO:0032041; GO:0032869; GO:0033558; GO:0034983; GO:0035097; GO:0042113; GO:0042826; GO:0045892; GO:0046872; GO:0048742; GO:0051153; GO:0070491; GO:0070932; GO:0070933; GO:0090050

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK1* (Q14012)	Homo sapiens	S220	FPLRKTASEPNLKVR	0.893	0.6906	U	likely	experimental	72 \| 8 \| 73 \|	12202037	-	In vivo
CAMK1* (Q14012)	Homo sapiens	S451	RPLNRTQSAPLPQST	0.938	0.8966	U	likely	experimental	72 \| 8 \| 73 \|	12202037	-	In vivo

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

NCI Nature PID Pathways

Pathway ID	Pathway Name
hdac_classi_pathway	Signaling events mediated by HDAC Class I
hdac_classii_pathway	Signaling events mediated by HDAC Class II