| Gene |
KIDINS220
|
| Protein Name |
KDIS_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) |
| Protein Family |
N/A |
| NCBI Gene ID |
57498
|
| UniProt ID |
Q9ULH0
|
| Enzyme Class |
- |
| Molecular Weight |
196542 |
| Protein Length |
1771 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Membrane Note=Localized at late endosome before or after nerve growth factor (NGF) stimulation. |
| Function (UniProt annotation) |
Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. |
| Gene Ontology |
GO:0000186; GO:0001701; GO:0005770; GO:0005829; GO:0010976; GO:0016020; GO:0016021; GO:0019887; GO:0030165; GO:0032991; GO:0038180; GO:0048813; GO:1990090 |
