Graphics credits: COMPARTMENTS | More Info
Parameter | Value |
---|---|
Gene | PHF8 |
Protein Name | PHF8_HUMAN |
Organism | Homo sapiens (Human) |
Alternative name(s) | Histone lysine demethylase PHF8 (EC 1.14.11.27) (PHD finger protein 8) |
Protein Family | JHDM1 histone demethylase family |
NCBI Gene ID | 23133 |
UniProt ID | Q9UPP1 |
Enzyme Class | 1.14.11.27 |
Molecular Weight | 117864 |
Protein Length | 1060 |
Protein Domain | InterPro | Pfam |
3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase | SwissModel |
Gene Expression | Gene Expression Atlas |
Function and Disease | OMIM |
Protein-protein Interaction Database | STRING | IntAct | MINT |
Kinase Database | Phospho.ELM | PhosphoSite | NetworKIN |
Catalytic Activity (UniProt annotation) | Protein N(6) |
Localization | Nucleus. Nucleus, nucleolus. Note=Recruited to H3K4me3 sites on chromatin during interphase. Dissociates from chromatin when cells enter mitosis. |
Function (UniProt annotation) | Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. |
Gene Ontology | GO:0000082; GO:0003682; GO:0005506; GO:0005634; GO:0005654; GO:0005730; GO:0007420; GO:0008270; GO:0016706; GO:0031965; GO:0032452; GO:0032454; GO:0033169; GO:0035064; GO:0035574; GO:0035575; GO:0045893; GO:0045943; GO:0051864; GO:0061188; GO:0070544; GO:0071557; GO:0071558 |
Gene Name | Organism | P-Site | Sequence(+/-7) | Conservation | Disorder | Curator Assessment | Reliability | Evidence Class | Evidence Logic | PubMed | Phospho-ELM | PhosphoSite-Plus |
---|---|---|---|---|---|---|---|---|---|---|---|---|
CHEK1 (O14757) | Homo sapiens | S904 | REGTRVASIETGLAA | 0.737 | 0.6375 | - | - | - | - | - | - |
|
Reactome Pathways
No KEGG pathways found
No NCI Nature pathways found