| Gene |
BAIAP2
|
| Protein Name |
BAIP2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) |
| Protein Family |
N/A |
| NCBI Gene ID |
10458
|
| UniProt ID |
Q9UQB8
|
| Enzyme Class |
- |
| Molecular Weight |
60868 |
| Protein Length |
552 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Note=Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites. |
| Function (UniProt annotation) |
Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. |
| Gene Ontology |
GO:0001221; GO:0001726; GO:0005654; GO:0005737; GO:0005791; GO:0005794; GO:0005829; GO:0005874; GO:0005886; GO:0005913; GO:0007009; GO:0007409; GO:0007420; GO:0008022; GO:0008093; GO:0008286; GO:0008360; GO:0009617; GO:0015629; GO:0016358; GO:0030141; GO:0030165; GO:0030175; GO:0030838; GO:0032956; GO:0035418; GO:0038096; GO:0042802; GO:0043025; GO:0043198; GO:0044306; GO:0048010; GO:0048167; GO:0051017; GO:0051764; GO:0060076; GO:0061003; GO:0061845; GO:0061846; GO:0070062; GO:0070064; GO:0071364; GO:0097060; GO:0097110; GO:0098641; GO:0098685; GO:0098978; GO:0099092; GO:0099523; GO:0099524; GO:0099564; GO:1905232; GO:1905274; GO:2000251; GO:2000463 |
