| Gene |
CAMK2A
|
| Protein Name |
KCC2A_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
815
|
| UniProt ID |
Q9UQM7
|
| Enzyme Class |
2.7.11.17 |
| Molecular Weight |
54088 |
| Protein Length |
478 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
Cell junction, synapse |
| Function (UniProt annotation) |
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). |
| Gene Ontology |
GO:0000082; GO:0000165; GO:0002931; GO:0004674; GO:0004683; GO:0005088; GO:0005516; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005829; GO:0005886; GO:0005954; GO:0006468; GO:0006816; GO:0007223; GO:0009931; GO:0010666; GO:0014069; GO:0016301; GO:0018105; GO:0030054; GO:0030666; GO:0035254; GO:0038166; GO:0042802; GO:0042803; GO:0043005; GO:0043197; GO:0045211; GO:0046777; GO:0046872; GO:0046928; GO:0048168; GO:0048813; GO:0051092; GO:0051928; GO:0060333; GO:0060996; GO:0098685; GO:0099148; GO:1902108; GO:1990443; GO:2001222 |
