| Gene |
TRPC6
|
| Protein Name |
TRPC6_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) |
| Protein Family |
Transient receptor (TC 1.A.4) family |
| NCBI Gene ID |
7225
|
| UniProt ID |
Q9Y210
|
| Enzyme Class |
- |
| Molecular Weight |
106326 |
| Protein Length |
931 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell membrane |
| Function (UniProt annotation) |
Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. |
| Gene Ontology |
GO:0003779; GO:0005261; GO:0005262; GO:0005737; GO:0005886; GO:0005887; GO:0006812; GO:0006828; GO:0007204; GO:0007338; GO:0007568; GO:0010800; GO:0015279; GO:0016020; GO:0030168; GO:0030182; GO:0030276; GO:0032414; GO:0034703; GO:0036057; GO:0042803; GO:0042805; GO:0045666; GO:0050774; GO:0051117; GO:0051480; GO:0051928; GO:0070301; GO:0070588; GO:0070679; GO:0071456 |
