CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	DAGLA
Protein Name	DGLA_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Sn1-specific diacylglycerol lipase alpha (DGL-alpha) (EC 3.1.1.-) (Neural stem cell-derived dendrite regulator)
Protein Family	AB hydrolase superfamily
NCBI Gene ID	747
UniProt ID	Q9Y4D2
Enzyme Class	3.1.1.-
Molecular Weight	114952
Protein Length	1042
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cell membrane; Multi-pass membrane protein.
Function (UniProt annotation)	Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.
Gene Ontology	GO:0005886; GO:0007216; GO:0007405; GO:0019369; GO:0022008; GO:0042136; GO:0043196; GO:0045211; GO:0046340; GO:0046872; GO:0047372; GO:0071926; GO:0098921; GO:0099055

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK2A (Q9UQM7)	Homo sapiens	S782	APLATMESLSDTESL	0.651	0.4801	-	-	-	-	-	-	in-vitro
CAMK2A (Q9UQM7)	Homo sapiens	S808	RSIRGSPSLHAVLER	0.387	0.5665	-	-	-	-	-	-	in-vitro

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found