CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	PPME1
Protein Name	PPME1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89)
Protein Family	AB hydrolase superfamily
NCBI Gene ID	51400
UniProt ID	Q9Y570
Enzyme Class	3.1.1.89
Molecular Weight	42315
Protein Length	386
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	CATALYTIC ACTIVITY: [Phosphatase 2A protein]-leucine methyl ester + H(2)O = [phosphatase 2A protein]-leucine + methanol.
Localization	N/A
Function (UniProt annotation)	Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.
Gene Ontology	GO:0000086; GO:0004864; GO:0005654; GO:0006482; GO:0019888; GO:0019901; GO:0019903; GO:0045296; GO:0051721; GO:0051722

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CHEK1 (O14757)	Homo sapiens	S15	MHLGRLPSRPPLPGS	0.126	0.7331	-	-	-	-	-	-	in-vitro

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found