| Gene |
NCOR2
|
| Protein Name |
NCOR2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor) |
| Protein Family |
N-CoR nuclear receptor corepressors family |
| NCBI Gene ID |
9612
|
| UniProt ID |
Q9Y618
|
| Enzyme Class |
- |
| Molecular Weight |
273657 |
| Protein Length |
2514 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus. |
| Function (UniProt annotation) |
Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). |
| Gene Ontology |
GO:0000118; GO:0000122; GO:0000790; GO:0000981; GO:0001012; GO:0003682; GO:0003714; GO:0005112; GO:0005634; GO:0005654; GO:0016020; GO:0016363; GO:0016604; GO:0017053; GO:0019216; GO:0035257; GO:0042826; GO:0043565; GO:0045892; GO:0047485; GO:0060766; GO:0072365; GO:1903799 |
