| Gene |
Cdh2
|
| Protein Name |
CADH2_RAT |
| Organism |
Rattus norvegicus (Rat) |
| Alternative name(s) |
Cadherin-2 (Neural cadherin) (N-cadherin) (CD antigen CD325) |
| Protein Family |
N/A |
| NCBI Gene ID |
83501
|
| UniProt ID |
Q9Z1Y3
|
| Enzyme Class |
- |
| Molecular Weight |
99686 |
| Protein Length |
906 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell membrane |
| Function (UniProt annotation) |
Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. |
| Gene Ontology |
GO:0005509; GO:0005737; GO:0005886; GO:0005913; GO:0005916; GO:0007043; GO:0007156; GO:0007416; GO:0008013; GO:0008092; GO:0009986; GO:0010001; GO:0014069; GO:0014704; GO:0016020; GO:0016339; GO:0016342; GO:0019901; GO:0030027; GO:0030315; GO:0031641; GO:0032880; GO:0032991; GO:0034332; GO:0035023; GO:0042803; GO:0043005; GO:0044331; GO:0044877; GO:0045177; GO:0045202; GO:0045296; GO:0048514; GO:0050770; GO:0050804; GO:0050998; GO:0051291; GO:0051966; GO:0097150; GO:0098609; GO:0098978; GO:0099059; GO:0099060; GO:0099560 |
