CaMKinet | Result

Gene

CASK

Synonyms

LIN2

Protein Name

Peripheral plasma membrane protein CASK

UniProt ID

O14936 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000367396

NCBI Gene ID

8573

Molecular Weight

105123

Protein Length

926

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 3c0g)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Localization

Nucleus,Cytoplasm,Cell membrane;

Function

Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.

Gene Ontology

GO:0015629; GO:0005604; GO:0016323; GO:0005911; GO:0060170; GO:0005737; GO:0005829; GO:0005925; GO:0005652; GO:0016363; GO:0005730; GO:0005886; GO:0042734; GO:0098685; GO:0031982; GO:0005524; GO:0005516; GO:0004385; GO:0042043; GO:0004674; GO:0070509; GO:0007155; GO:0001953; GO:0090288; GO:0010839; GO:0061045; GO:0007269; GO:0090280; GO:0045944; GO:2000300