Dapk3 | Death-associated protein kinase 3
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Kinase Substrate Both Localization legend

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Sequence Viewer
Gene
Synonyms
Zipk
Protein Name
Death-associated protein kinase 3
UniProt ID
O54784 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
51422
Protein Length
448
Protein Domain
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
2.7.11.1; (BRENDA)
Catalytic Site
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Nucleus,Nucleus,PML body,Cytoplasm,Cytoskeleton,Microtubule organizing center,Centrosome,Chromosome,Centromere,Cytoplasm;
Function
Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in formation of promyelocytic leukemia protein nuclear body (PML-NB). Involved in apoptosis involving PAWR which mediates cytoplasmic relocation; in vitro phosphorylates PAWR (By similarity). Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton such as in regulation of cell polarity and cell migration. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2; disrupts the NLK-TCF7L2 complex thereby influencing the phosphorylation of TCF7L2 by NLK. Phosphorylates STAT3 and enhances its transcriptional activity. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis (By similarity). Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition.
Gene Ontology
GO:0005884; GO:0000775; GO:0005737; GO:0045121; GO:0005815; GO:0005634; GO:0016605; GO:0005524; GO:0042802; GO:0016301; GO:0043522; GO:0008022; GO:0042803; GO:0004674; GO:0017048; GO:0006915; GO:0097190; GO:0071346; GO:0006325; GO:0035556; GO:0017148; GO:0030182; GO:0043065; GO:0090263; GO:0030335; GO:2001241; GO:0046777; GO:0006468; GO:2000249; GO:0008360; GO:0051893; GO:0007346; GO:0043519


Gene Ontology (click on any section to view sub-classification)