STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Nucleus,Nucleus,PML body,Cytoplasm,Cytoplasm,Cytoskeleton,Microtubule organizing center,Chromosome,Centromere,Cytoplasm,Cytoskeleton;

Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in formation of promyelocytic leukemia protein nuclear body (PML-NB). Involved in apoptosis involving PAWR which mediates cytoplasmic relocation; in vitro phosphorylates PAWR. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton such as in regulation of cell polarity and cell migration. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2; disrupts the NLK-TCF7L2 complex thereby influencing the phosphorylation of TCF7L2 by NLK. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition (By similarity). Phosphorylates STAT3 and enhances its transcriptional activity (By similarity). Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis.

GO:0005884; GO:0000775; GO:0005737; GO:0045121; GO:0005634; GO:0016605; GO:0005524; GO:0016301; GO:0043522; GO:0008022; GO:0042803; GO:0004674; GO:0017048; GO:0006915; GO:0097190; GO:0071346; GO:0006325; GO:0035556; GO:0017148; GO:0030182; GO:0043065; GO:0090263; GO:0030335; GO:2001241; GO:0046777; GO:2000249; GO:0008360; GO:0051893; GO:0007346; GO:0043519