Protein Name
Calcium/calmodulin-dependent protein kinase type II subunit gamma
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
59038
Protein Length
527
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Sarcoplasmic reticulum membrane;
Function
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning (By similarity).
Gene Ontology
GO:0005737; GO:0043005; GO:0033017; GO:0005524; GO:0005516; GO:0004683; GO:0030154; GO:0007399; GO:0046777; GO:0048169; GO:1903076; GO:0001666; GO:0006979