PHKG2 | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Kinase Substrate Both Localization legend

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Sequence Viewer
Gene
PHKG2
Synonyms
-
Protein Name
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
UniProt ID
P15735 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000388571
NCBI Gene ID
5261
Molecular Weight
46442
Protein Length
406
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 2y7j)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
2.7.11.19; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
2 ATP + phosphorylase b = 2 ADP + phosphorylase a.
Localization
Function
Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity).
Gene Ontology
GO:0005829; GO:0005964; GO:0005524; GO:0005516; GO:0004683; GO:0019899; GO:0004689; GO:0004674; GO:0050321; GO:0006091; GO:0005978; GO:0005977; GO:0045819; GO:0006468