CaMKinet | Result

Gene

Mark3

Synonyms

Emk2 Mpk10

Protein Name

MAP/microtubule affinity-regulating kinase 3

UniProt ID

Q03141 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSMUSP00000074757

NCBI Gene ID

17169

Molecular Weight

84390

Protein Length

753

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1ul7)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Localization

Cell membrane,Cell projection,Dendrite,Cytoplasm;

Function

Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAPT/TAU, MAP2 and MAP4. Phosphorylates CDC25C. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1.

Gene Ontology

GO:0005737; GO:0030425; GO:0005886; GO:0005524; GO:0004674; GO:0050321; GO:0030010; GO:0035556; GO:0000226; GO:0035331; GO:0036289; GO:0018105; GO:0032092; GO:0006468