CaMKinet | Result

Gene

MYLK3

Synonyms

MLCK

Protein Name

Myosin light chain kinase 3

UniProt ID

Q32MK0 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000378288

NCBI Gene ID

91807

Molecular Weight

88393

Protein Length

819

Protein Domain

InterPro | Pfam

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.18; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

[myosin light chain]-L-serine + ATP = [myosin light chain]-O-phospho-L-serine + ADP + H(+)[myosin light chain]-L-threonine + ATP = [myosin light chain]-O-phospho-L-threonine + ADP + H(+)

Localization

Cytoplasm;

Function

Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity).

Gene Ontology

GO:0015629; GO:0005737; GO:0005829; GO:0005524; GO:0004683; GO:0004687; GO:0055003; GO:0071347; GO:0060298; GO:0006468; GO:0002528; GO:0045214; GO:0048769