CaMKinet | Result

Gene

TSSK4

Synonyms

C14orf20 STK22E TSSK5

Protein Name

Testis-specific serine/threonine-protein kinase 4

UniProt ID

Q6SA08 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000287913

NCBI Gene ID

283629

Molecular Weight

37454

Protein Length

328

Protein Domain

InterPro | Pfam

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Localization

Cytoplasmic vesicle,Secretory vesicle,Acrosome,Cell projection,Cilium,Flagellum;

Function

Serine/threonine kinase which is involved in male germ cell development and in mature sperm function (By similarity). May be involved in the Cre/Creb signaling pathway (By similarity). Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (PubMed:15964553). Phosphorylates CREM on 'Ser-116' in vitro (By similarity). Phosphorylates ODF2 on 'Ser-95' (By similarity).

Gene Ontology

GO:0001669; GO:0005737; GO:0031514; GO:0005634; GO:0005524; GO:0000287; GO:0004674; GO:0030154; GO:0035556; GO:0007275; GO:0032793; GO:0006468; GO:0007283