CaMKinet | Result

Gene

Sik2

Synonyms

Snf1lk2

Protein Name

Serine/threonine-protein kinase SIK2

UniProt ID

Q8CFH6 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

NCBI Gene ID

235344

Molecular Weight

104198

Protein Length

931

Protein Domain

InterPro | Pfam

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Localization

Cytoplasm;

Function

Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling (PubMed:29211348).

Gene Ontology

GO:0005737; GO:0031588; GO:0005634; GO:0005524; GO:0000287; GO:0004674; GO:0042149; GO:0008286; GO:0035556; GO:0032007; GO:0046777; GO:0006468; GO:0046626