CAMKK1 | Calcium/calmodulin-dependent protein kinase kinase 1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Kinase Substrate Both Localization legend

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Sequence Viewer
Gene
CAMKK1
Synonyms
CAMKKA
Protein Name
Calcium/calmodulin-dependent protein kinase kinase 1
UniProt ID
Q8N5S9 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000158166
NCBI Gene ID
84254
Molecular Weight
55735
Protein Length
505
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 6ccf)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
2.7.11.17; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Cytoplasm,Nucleus;
Function
Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.
Gene Ontology
GO:0005737; GO:0005829; GO:0005634; GO:0005524; GO:0005516; GO:0004683; GO:0004674; GO:0035556; GO:0045860