CaMKinet | Result

Gene

MARK4

Synonyms

KIAA1860 MARKL1

Protein Name

MAP/microtubule affinity-regulating kinase 4

UniProt ID

Q96L34 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000262891

NCBI Gene ID

57787

Molecular Weight

82520

Protein Length

752

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 5es1)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Localization

Cytoplasm,Cytoskeleton,Microtubule organizing center,Centrosome,Cytoplasm,Cytoskeleton,Microtubule organizing center,Cytoplasm,Cytoskeleton,Cilium basal body,Cytoplasm,Cytoskeleton,Cilium axoneme,Cytoplasm,Cell projection,Dendrite;

Function

Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942).

Gene Ontology

GO:0005813; GO:0036064; GO:0005737; GO:0005829; GO:0030425; GO:0000930; GO:0015630; GO:0005815; GO:0030496; GO:0043005; GO:0005524; GO:0043015; GO:0008017; GO:0004674; GO:0048156; GO:0050321; GO:0043130; GO:0007049; GO:0051301; GO:0097711; GO:0044782; GO:0030010; GO:0035556; GO:0001578; GO:0000226; GO:0007399; GO:0045724; GO:0043068; GO:1904781; GO:0006468; GO:0046605