Protein Name
PAS domain-containing serine/threonine-protein kinase
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
142929
Protein Length
1323
Protein Domain
3D Structure
(PDB ID : 3dls)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Cytoplasm,Nucleus;
Function
Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.
Gene Ontology
GO:0005737; GO:0005829; GO:0005634; GO:0005524; GO:0035091; GO:0004674; GO:0097009; GO:0035556; GO:0045719; GO:0045727; GO:0046777; GO:0006468; GO:0070092; GO:0043576