CaMKinet | Result

Gene

MKNK1

Synonyms

MNK1

Protein Name

MAP kinase-interacting serine/threonine-protein kinase 1

UniProt ID

Q9BUB5-2 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000361013

NCBI Gene ID

8569

Molecular Weight

51342

Protein Length

465

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2hw6)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Localization

Isoform 2: Cytoplasm;Isoform 3: Cytoplasm,Nucleus;

Function

May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.

Gene Ontology

GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0005524; GO:0009931; GO:0005516; GO:0004683; GO:0046872; GO:0004674; GO:0035556; GO:0018105; GO:0046777; GO:0006468; GO:0006417