NUAK2 | NUAK family SNF1-like kinase 2
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Kinase Substrate Both Localization legend

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Sequence Viewer
Gene
NUAK2
Synonyms
OMPHK2 SNARK
Protein Name
NUAK family SNF1-like kinase 2
UniProt ID
Q9H093 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000356125
NCBI Gene ID
81788
Molecular Weight
69612
Protein Length
628
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
2.7.11.1; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Function
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.
Gene Ontology
GO:0005737; GO:0005634; GO:0005524; GO:0000287; GO:0004674; GO:0030036; GO:0006915; GO:0042149; GO:0035556; GO:0043066; GO:0006468