Protein Name
Death-associated protein kinase 2
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
42898
Protein Length
370
Protein Domain
3D Structure
(PDB ID : 1zws)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Cytoplasm,Cytoplasmic vesicle,Autophagosome lumen;
Function
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421).Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.
Gene Ontology
GO:0034423; GO:0005737; GO:0031410; GO:0005794; GO:0043231; GO:0005634; GO:0005524; GO:0005516; GO:0042802; GO:0004674; GO:0043276; GO:0006915; GO:0035556; GO:1990266; GO:2000424; GO:0090023; GO:0046777; GO:0006468; GO:0042981; GO:0010506; GO:2001242