SIK3 | Serine/threonine-protein kinase SIK3
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Kinase Substrate Both Localization legend

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Sequence Viewer
Gene
SIK3
Synonyms
KIAA0999 QSK
Protein Name
Serine/threonine-protein kinase SIK3
UniProt ID
Q9Y2K2 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000364449
NCBI Gene ID
23387
Molecular Weight
144851
Protein Length
1321
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
2.7.11.1; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Cytoplasm;
Function
Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling.
Gene Ontology
GO:0005737; GO:0005524; GO:0000287; GO:0004674; GO:0050321; GO:0035556; GO:0000226; GO:0006468