Ryr2 | Ryanodine receptor 2
 
Sequence Viewer
Gene
Ryr2
Synonyms
-
Protein Name
Ryanodine receptor 2
UniProt ID
B0LPN4 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
-
NCBI Gene ID
689560
Molecular Weight
562955
Protein Length
4953
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 2k2f)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Sarcoplasmic reticulum membrane,Membrane,Sarcoplasmic reticulum;
Function
Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development (By similarity).
Gene Ontology
GO:0031672; GO:0034704; GO:0005737; GO:0030659; GO:0005783; GO:0031234; GO:0043005; GO:0005635; GO:0005886; GO:0032991; GO:0042383; GO:0016529; GO:0033017; GO:0005790; GO:0030018; GO:0005262; GO:0005509; GO:0048763; GO:0015278; GO:0005516; GO:0005219; GO:0097110; GO:0070588; GO:0006816; GO:0019722; GO:0006874; GO:0071313; GO:0003143; GO:0034220; GO:0071421; GO:0051481; GO:0051480; GO:0051209; GO:0051592; GO:0042493; GO:0032026; GO:0007584; GO:0070296
 
Gene Ontology