Protein Name
Cellular tumor antigen p53
UniProt ID
Ensembl Gene ID
-
NCBI Gene ID
Molecular Weight
43653
Protein Length
393
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Nucleus;
Function
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
Gene Ontology
GO:0005737; GO:0005654; GO:0003700; GO:0046872; GO:0044212; GO:0006915; GO:0007049; GO:0051262