Function
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:27022195). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:9237759, PubMed:10835634, PubMed:27022195). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Responses triggered by Ni(2+) require non-conserved histidines and are, therefore, species-specific (PubMed:20711192). Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression (PubMed:15809303). In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via TLR2, but also partially via this receptor (PubMed:16622205).
Gene Ontology
GO:0009986; GO:0005737; GO:0005769; GO:0010008; GO:0009897; GO:0005887; GO:0031226; GO:0046696; GO:0048471; GO:0005886; GO:0043235; GO:0001540; GO:0042802; GO:0001530; GO:0001875; GO:0046982; GO:0038023; GO:0005102; GO:0004888; GO:0000187; GO:0097190; GO:0014002; GO:0002322; GO:1904646; GO:0071346; GO:0071222; GO:0071223; GO:0071260; GO:0140052; GO:0042742; GO:0050829; GO:0016046; GO:0032497; GO:0007249; GO:0007252; GO:0006955; GO:0006954; GO:0045087; GO:0032609; GO:0050702; GO:0060729; GO:0031663; GO:0042116; GO:0002755; GO:0002756; GO:0070266; GO:0120163; GO:0070373; GO:0032689; GO:0032700; GO:0032707; GO:0032715; GO:0034128; GO:0045671; GO:0032720; GO:0002537; GO:0030890; GO:1903974; GO:0032722; GO:1900017; GO:0070374; GO:0010628; GO:0043123; GO:0050729; GO:0032727; GO:0045359; GO:0032728; GO:0032729; GO:0050718; GO:0032732; GO:0032733; GO:0045084; GO:0032735; GO:0032755; GO:0045416; GO:0032757; GO:0046330; GO:0043032; GO:0060907; GO:0045348; GO:0051092; GO:1901224; GO:0045429; GO:0051770; GO:1900227; GO:0070430; GO:0070434; GO:1903223; GO:0010572; GO:1903428; GO:0045944; GO:0042535; GO:0032760; GO:0002730; GO:0032496; GO:0042088; GO:0034142; GO:0002224; GO:0035666