E2F3 | Transcription factor E2F3
 
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Sequence Viewer
Gene
E2F3
Synonyms
KIAA0075
Protein Name
Transcription factor E2F3
UniProt ID
O00716-1 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000262904
NCBI Gene ID
1871
Molecular Weight
49162
Protein Length
465
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus;
Function
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity).
Gene Ontology
GO:0005654; GO:0005634; GO:0090575; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0046983; GO:0000987; GO:0043565; GO:0008134; GO:0007049; GO:0070345; GO:0000122; GO:0008284; GO:0045944; GO:1905461; GO:0051726; GO:0006367
 
Gene Ontology