ACACB | Acetyl-CoA carboxylase 2
 
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Sequence Viewer
Gene
ACACB
Synonyms
ACC2 ACCB
Protein Name
Acetyl-CoA carboxylase 2
UniProt ID
O00763 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000341044
NCBI Gene ID
32
Molecular Weight
276541
Protein Length
2458
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 2dn8)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
6.4.1.2; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
acetyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + malonyl-CoA + phosphateATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate
Localization
Mitochondrion,Nucleus,Endomembrane system;
Function
Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl-CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity).
Gene Ontology
GO:0005829; GO:0012505; GO:0005741; GO:0005739; GO:0005634; GO:0003989; GO:0005524; GO:0009374; GO:0004075; GO:0042802; GO:0046872; GO:0006084; GO:0006853; GO:0097009; GO:0006633; GO:2001295; GO:0043086; GO:0031999; GO:0010629; GO:0031325; GO:0060421; GO:0010884; GO:0051289; GO:0045540; GO:0010906; GO:0042493; GO:0031667; GO:0014070
 
Gene Ontology