CaMKinet | Result

Gene

APAF1

Synonyms

KIAA0413

Protein Name

Apoptotic protease-activating factor 1

UniProt ID

O14727 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000334558

NCBI Gene ID

317

Molecular Weight

141840

Protein Length

1248

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1c15)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Cytoplasm;

Function

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.

Gene Ontology

GO:0043293; GO:0005829; GO:0070062; GO:0005576; GO:1904813; GO:0005634; GO:0032991; GO:0034774; GO:0043531; GO:0005524; GO:0008656; GO:0031072; GO:0042802; GO:0000166; GO:0006919; GO:0008635; GO:0007568; GO:0006915; GO:0010659; GO:0030154; GO:0071560; GO:0030900; GO:0097193; GO:0070059; GO:0001822; GO:0070317; GO:0007399; GO:0001843; GO:0051402; GO:0043312; GO:0043065; GO:2001235; GO:0051260; GO:1902510; GO:0042981; GO:0072432; GO:0001666; GO:0007584