SLC9A3R1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
SLC9A3R1
Synonyms
NHERF NHERF1
Protein Name
Na(+)/H(+) exchange regulatory cofactor NHE-RF1
UniProt ID
O14745 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000262613
NCBI Gene ID
9368
Molecular Weight
38868
Protein Length
358
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 1g9o)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cytoplasm,Apical cell membrane,Endomembrane system,Cell projection,Filopodium,Cell projection,Ruffle,Cell projection,Microvillus;
Function
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa.
Gene Ontology
GO:0015629; GO:0016324; GO:0031526; GO:0071944; GO:0005737; GO:0012505; GO:0070062; GO:0030175; GO:0016020; GO:0045121; GO:0005902; GO:0031528; GO:0048471; GO:0001726; GO:0097225; GO:0032426; GO:0031982; GO:0031698; GO:0008013; GO:0017081; GO:0050780; GO:0070851; GO:0045159; GO:0030165; GO:0019902; GO:0047485; GO:0043621; GO:0044877; GO:0032947; GO:0005102; GO:0030036; GO:0007191; GO:0060088; GO:0032782; GO:0030643; GO:0045198; GO:0051683; GO:0022612; GO:0034635; GO:0030033; GO:0090090; GO:0030336; GO:0008285; GO:0070373; GO:0045930; GO:0014067; GO:0010642; GO:0051898; GO:0032416; GO:0007097; GO:0060158; GO:2001244; GO:0034767; GO:0072659; GO:0065003; GO:0008360; GO:0008361; GO:0044062; GO:0045859; GO:0032415; GO:0070293; GO:0097291; GO:0003096; GO:0007605; GO:0016055
 
Gene Ontology